While in Rio de Janeiro, medical student Natalie Reyes is kidnapped, shot and left for dead. Halfway around the world, Joe Anson is working on a serum that could save millions - but he's running out of time. In Chicago, detective Ben Callahan tries to find the identity of a dead man. Three people, with no apparent connection.
Gabe Singleton is a country doctor and his friend Andrew Stoddard is now the US President. When the president's physician disappears, Gabe is called on to take his place. He soon realizes the president is going insane and that the condition may not be of natural causes. Who? Why? And how?
When Dr. Thea Sperelakis' father is severely injured by a hit-and-run driver, her siblings demand that treatment be withheld. While Petros lingers in intensive care, Thea uncovers the facts surrounding the disaster, which looks more and more to be no accident. Petros himself is the only witness and the answers are trapped in his brain...until he begins to blink a terrifying message.