An Italian Wife opens in turn-of-the-century Italy, when young Josephine Rimaldi is forced to follow her new husband to America in an arranged marriage and finds herself in a strange country with a man she doesn't know or love. Bound by tradition, she gives birth to seven children; the last, conceived in a passionate affair, Josephine must give up for adoption. Josephine spends the rest of her life searching for this child, keeping her secret even as her other children, whose stories unfold in surprising ways, go off to war, get married, and make their own mistakes,